(Ph.D.) Gwangju Institute of Science and Technology, Korea (2002)
약력/경력
2007~ present: Professor, Sungkyunkwan University
2003~2007 : Postdoctoral Fellow, National Institute on Aging/NIH
2002~2003 : Research Scientist, Phenomena and Function Research Institute, GIST
학술지 논문
(2022)
Physiology and pharmacology of amyloid precursor protein.
PHARMACOLOGY & THERAPEUTICS.
235,
1
(2022)
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection.
JOURNAL OF EXTRACELLULAR VESICLES.
11,
1
(2021)
Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p.
JOURNAL OF EXTRACELLULAR VESICLES.
10,
12
(2021)
Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function.
THERANOSTICS.
11,
18
(2021)
Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway.
PROGRESS IN NEUROBIOLOGY.
198,
1
(2021)
O-GIcNAcylation ameliorates the pathological manifestations of Alzheimer's disease by inhibiting necroptosis.
SCIENCE ADVANCES.
7,
3
(2021)
Neuronal Aquaporin 1 Inhibits Amyloidogenesis by Suppressing the Interaction Between Beta-Secretase and Amyloid Precursor Protein.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.
76,
1
(2020)
White matter and neurological disorders.
ARCHIVES OF PHARMACAL RESEARCH.
43,
9
(2020)
Human adipose stem cell-derived extracellular nanovesicles for treatment of chronic liver fibrosis.
JOURNAL OF CONTROLLED RELEASE.
320,
(2020)
Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration.
JOURNAL OF EXTRACELLULAR VESICLES.
9,
1
(2020)
Cell reprogramming using extracellular vesicles from differentiating stem cells into white/beige adipocytes.
SCIENCE ADVANCES.
6,
13
(2020)
SERP1 is an assembly regulator of gamma-secretase in metabolic stress conditions.
SCIENCE SIGNALING.
13,
623
(2020)
O-GlcNAcylation as a Therapeutic Target for Alzheimer's Disease.
NEUROMOLECULAR MEDICINE.
22,
2
(2019)
Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.
AUTOPHAGY.
15,
9
(2019)
Genome-Wide Transcriptome Analysis Reveals Intermittent Fasting-Induced Metabolic Rewiring in the Liver.
DOSE-RESPONSE.
17,
3
(2019)
NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
116,
25
(2019)
Therapeutic Approaches to Alzheimer's Disease Through Modulation of NRF2.
NEUROMOLECULAR MEDICINE.
21,
1
(2018)
Interplay between Notch and p53 promotes neuronal cell death in ischemic stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.
38,
10
단행본
(2015)
약품생화학 분자생물학 총정리.
신일서적(주).
공동
(2011)
약품생화학실험.
도서출판 신일북스.
주저자
(2010)
건강전문직을 위한 핵심 약리학.
FORNURSE.
주저자
(2009)
약품생화학총정리.
동명사.
공동
특허/프로그램
COMPOSITION FOR PREVENTING OR OTHER PUBLICATIONS TREATING NEURODEGENERATIVE DISEASES , CONTAINING RAMALIN.
15/520,100.
20180515.
미국
PHARMACEUTICAL AND FOOD COMPOSITION FOR PREVENTING OR TREATING DIABETES OR OBESITY.
WO/2012/046945.
20180124.
EU연합
COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASES INCLUDING COMPOUND DOWNREGULATING EXPRESSION OF BACE1 PROTEINS.
14330583.
20170124.
미국
BACE1 단백질의 발현을 조절하는 물질을 포함한 퇴행성 뇌 질환 에방 치료용 조성물.
10-2014-0069137.
20161115.
미국
BACE1 단백질의 발현을 조절하는 물질을 포함한 퇴행성 뇌 질환 에방 치료용 조성물.
14/330,583 .
20160708.
대한민국
라말린을 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물.
10-2014-0144984.
20160701.
대한민국
L-Histidine, hydrazide를 포함한 알츠하이머 질환 예방 및 치료용 조성물.
10-2012-0052866.
20140324.
대한민국
감마 세크레타제 저해제를 유효성분으로 포함하는 류마티스성 관절염 예방 또는 치료용 조성물.
10-1330184.
20131111.
대한민국
감마 세크레타제 저해제를 유효성분으로 포함하는 류마티스성 관절염 예방 또는 치료용 조성물.
10-1300017.
20130820.
대한민국
감마 세크레타제 저해제를 유효성분으로 포함하는 류마티스성 관절염 예방 또는 치료용 조성물.
10-1300016.
20130820.
대한민국
스테레오카울론 알피넘 유래 화합물을 함유하는 당뇨병 또는 비만의 예방 또는 치료용 약학 조성물(Pharmaceutical Composition for Preventing or Treating Diabetes or Obesity Containing Compounds Derived from Stereocaulon alpinum).
10-1185137-0000.
20120917.
대한민국
학술회의논문
(2020)
Altered Expression of Adiponectin in Alzheimer's Disease.
International Conference : Korean Society for Molecular and Cellular Biology.
대한민국
(2020)
Sulforaphane Negatively Regulates BACE1 Expression and Rescues Cognitive Impairments in AD Mouse Models through The Activation of NRF2.
International Conference : Korean Society for Molecular and Cellular Biology.
대한민국
(2020)
Cell reprogramming using extracellular vesicles from differentiating stem cells into white/beige adipocytes.
The 7th International Symposium of Stem Cell & Regenerative Medicine Institute.
대한민국
(2019)
NRF2 is a Negative Regulator of BACE1 Expression in Alzheimer's Disease.
기초의과학연구센터(MRC) 2019 연합성과발표회.
대한민국
(2019)
Analysis of the adiponectin expression in alzheimer's disease.
2019 Fall international convention of the pharmaceutical society of Korea.
대한민국
(2019)
Epigenetic regulation Of BACE1 expression via dCas9-DNMT3A system.
2019 Fall international convention of the pharmaceutical society of Korea.
대한민국
(2019)
NRF2 is a negative regulator of BACE1.
제48차 한국세포생물학회.
대한민국
(2019)
A novel compound derived from antarctic lichen prevents progression of alzheimer's disease.
The 14th international conference on Alzheimer's & Parkinson's Disease.
포르투갈
(2019)
Adipose-derived stem cell exosome regulates ERK-MAPK pathway in vitro PD model.
The 14th international conference on Alzheimer's & Parkinson's Disease.
포르투갈
(2019)
Analysis of the adiponectin expression in alzheimer's disease.
The 14th international conference on Alzheimer's & Parkinson's Disease.
포르투갈
(2019)
Familial Alzheimer's disease causing presenilin-1 mutations in mitochondrial Dysfunction.
The 14th international conference on Alzheimer's & Parkinson's Disease.
포르투갈
(2019)
NRF2 negatively regulates BACE1 and BACE1-AS expression.
The 14th international conference on Alzheimer's & Parkinson's Disease.
포르투갈
(2019)
Epigenetic regulation Of BACE1 expression via dCas9-DNMT3A system.
The 14th international conference on Alzheimer's & Parkinson's Disease.
포르투갈
(2018)
Role of Alzheimer's disease-causing presenilin-1 mutations in mitochondrial dynamics.
기초의과학연구센터(MRC) 2018 연합성과발표회.
대한민국
(2018)
Inhibition of Drp1 ameliorates synaptic depression, Aβ depositionn and memory deficit in Alzheimer's disease model.
2018 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2018)
Role of Alzheimer's disease-causing presenilin-1 mutations in mitochondrial dynamics.
2018 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2018)
Role of adiponectin signaling in the pathogenesis of Alzheimer's disease.
2018 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2018)
Pharmacologic treatment with Drp1 inhibitor(Mdivi-1) recovers mitochondrial dysfunction in Alzheimer's disease.
2018 Annual Meeting of the Korean Society of Applied Pharmacology.
대한민국
